The best way to reach Drama is by the Bus, frequently travelling from Thessaloniki 15euro for a single ticket, you can also travel there by train but the train station is about a 10 minute walk from the centre of the city. The bus station is about 3 minutes from the center of the city near "plateia elefterias" freedom square the main square.
By ship
The nearest harbour is Kavala, mainly serving the routes between Kavala-Thassos-Samothraki.
By bus
You can take the KTEL Greek national busservice from Thessaloniki around 2 hours, 15 euro or Kavala.
By plane
You can travel to Kavala international airport and then catch a bus to Drama.
By train
You can get a train from either Thessaloniki or Athens. Cost is cheaper than the bus.
By car
With the now completed "Egnatia" freeway you can reach Drama in less then 2 hours from Thessaloniki, and around 30 minutes from Kavala.